ABSTRACT
Objective To evaluate the intervention effect of dietary interventions in newly-admitted children in kindergartens and nurseries. Methods Newly-admitted children from 6 kindergartens and nurseries were randomly divided into intervention group and control group, and prospective controlled trials were conducted. The intervention group took a one-year comprehensive intervention measures, and the control group took conventional interventions, evaluation of the intervention effect. Results Before intervention, the parents of children had the highest content of protein in plant foods, which are the main nutrients in cereals, and the awareness rate was 62.08％ and 63.34％ respectively. About 74.05％ of the children need help when eating and 67.54％ of the children always skip breakfast. Generalized estimation equation analysis showed that after intervention, the awareness rate of various parents 'nutritional knowledge increased (P<0.05), and the increase rate of parents' awareness in the intervention group was greater than that of the control group (P<0.05) . After the intervention, the positive rate of various unhealthy eating habits among children decreased (P<0.05), and the positive rate of multiple unhealthy eating habits in the intervention group was greater than that of the control group (P<0.05) . Conclusion The family-school-children comprehensive intervention can effectively improve patient's awareness of nutritional knowledge and reduce the occurrence of unhealthy dietary behaviors of children in private nurseries.
ABSTRACT
Hedgehog (HH) signaling pathway was firstly discovered in the regulation of embryonic segments development in Drosophila; later, the biochemical and functional homologs of Drosophila HH signaling genes were also isolated in vertebrates (including human). Researchers found that HH signaling not only controls the embryonic development, but also plays an important role in tumorigenesis. Gli, a zinc finger transcription factor in the vertebral HH signaling pathway, combines to the special sequences of distal HH targeted genes and directly controls the transcription of targeted genes, playing a key role in HH signaling pathway. In this article, we summarize the role of Gli in HH signaling pathway and its prospect in cancer therapy.